CYCLIC MELANOCORTIN AGONIST
In stock
MT-II takes alpha-MSH and bends it into a ring. The circular structure makes it tougher and far more potent — and unlike MT-I, it activates the whole melanocortin receptor family rather than a single member.
That breadth is exactly what labs use it for: a standard screening tool for comparing melanocortin-receptor subtypes, and for studying how a cyclic structure changes a peptide's stability and reach.
Keep the sealed vials in the fridge and out of direct light — they’ll hold up for a long time that way. Once a vial is mixed, keep it refrigerated and use it within the window your protocol calls for.
Every batch we sell is tested by an independent U.S. lab before it goes up for sale — that report is the certificate of analysis, and a copy is included with every order. Want the one for your exact vial? Email the lot number printed on the label to [email protected] and we’ll send it over within one business day.
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Also referenced as: MT-II · melanotan II · cyclic α-MSH analogue
MT-II takes alpha-melanocyte-stimulating hormone and bends it into a ring: a lactam bridge locks the peptide's active core into a rigid cycle, producing a compact seven-residue molecule that is tougher, longer-lived and substantially more potent than the linear hormone.
The cyclization has a second consequence: where MT-I stays selective for the MC1 receptor, MT-II activates several members of the melanocortin receptor family — MC1R, MC3R, MC4R and MC5R. That breadth defines its research role.
MT-II is the classic pan-melanocortin screening tool. Receptor-subtype comparison studies use it as the broad agonist against which selective ligands are profiled, and pigmentation research uses it for potent MC1R engagement in melanocyte and animal models.
Because MC3R and MC4R are central to energy-balance and appetite circuits in the brain, MT-II also appears widely in preclinical studies of those pathways — a reminder that the melanocortin system reaches well beyond pigment. It's equally a structural case study: the standard example of how cyclization changes a peptide's stability, potency and selectivity at once.
Verified at 99.0%+ purity, supplied lyophilized with batch identity and endotoxin screening. The cyclic structure makes it one of the hardier peptides in the catalog, though standard storage discipline still applies.
Run beside MT-I, it completes the receptor-mapping pair: one selective probe, one broad one, same verification standard.
The published record runs deeper than any product page should. For the primary literature, browse MT-II studies on PubMed. For how every batch we sell is verified, see how we test.
From our research library: What “research use only” actually means. · The melanocortin system, mapped.
No. MT-II is supplied strictly for laboratory research. It is not for human or veterinary use, and every order requires agreement to our research-use policy.
A ring can't be unraveled from its ends by exopeptidases, and rigidity locks the active conformation in place — so cyclization simultaneously raises stability and potency while broadening which melanocortin receptors the fixed shape fits. MT-II is the textbook demonstration of all three effects.
No — that's its best-known territory, but its MC3R/MC4R activity places it in a substantial preclinical literature on appetite and energy-balance signalling. In receptor terms it's a family-wide agonist, and its research footprint matches.
The current batch is 99.1% pure by HPLC, tested by an independent US laboratory before sale — along with identity confirmation and endotoxin screening below 0.5 EU/mg. The certificate of analysis is included with every order, and the report for any specific vial is available by emailing its lot number.
MT-II is available in 10mg vials of lyophilized powder. Quantity discounts apply automatically at checkout.
Keep sealed vials frozen at −20 °C and away from light. Once reconstituted, hold the solution at 2–8 °C and use it within the window your laboratory protocol defines.
