TRIPLE RECEPTOR AGONIST
In stock
GLP-3R is the most ambitious compound in our metabolic line — one peptide built to reach three receptors at once: GLP-1, GIP and glucagon. That triple design is what's made it one of the most talked-about molecules in metabolic research right now.
Labs use it to study how those three signals behave together — how a multi-receptor compound compares to single-target ones in appetite, blood-sugar and energy-balance models, and what each receptor contributes to the whole.
Keep the sealed vials in the fridge and out of direct light — they’ll hold up for a long time that way. Once a vial is mixed, keep it refrigerated and use it within the window your protocol calls for.
Every batch we sell is tested by an independent U.S. lab before it goes up for sale — that report is the certificate of analysis, and a copy is included with every order. Want the one for your exact vial? Email the lot number printed on the label to [email protected] and we’ll send it over within one business day.
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Also referenced as: GLP-1/GIP/glucagon triple receptor agonist · triple incretin agonist
GLP-3R is a single synthetic peptide engineered to activate three metabolic receptors at once: the GLP-1 receptor, the GIP receptor and the glucagon receptor. Each of those receptors normally answers to its own hormone; building one molecule that reaches all three is the frontier of incretin engineering, and it's what makes this the most ambitious compound in our metabolic line.
Structurally it belongs to the same family as our GLP-1 and GLP-2T peptides — a modified incretin backbone carrying a fatty-acid chain that binds serum albumin, which is what stretches its activity from minutes into days in circulation. The triple-receptor profile comes from carefully chosen substitutions along the chain that let it dock convincingly at all three receptors.
Triple agonism is studied because the three receptors pull different levers: GLP-1 signalling is tied to satiety and glucose-dependent insulin release, GIP to insulin response and adipose signalling, and glucagon to energy expenditure. A molecule that engages all three lets researchers ask what the combination does that no single signal can — and which receptor contributes what.
In practice, labs use GLP-3R in receptor-activation assays, comparative pharmacology against single and dual agonists, and preclinical models of appetite, glucose regulation and energy balance. Because the class is so young, much of the published work is head-to-head profiling — exactly the kind of study a well-characterized reference vial supports.
GLP-3R ships as lyophilized powder, ≥99% pure by HPLC, with identity and endotoxin verified batch-by-batch by an independent US lab. Like all long-chain acylated peptides it's sensitive to repeated temperature swings — store it lyophilized at −20 °C and reconstitute only what a protocol will use.
It sits naturally alongside our GLP-1 (single agonist) and GLP-2T (dual agonist) vials for ladder studies: one, two and three receptors, same supplier, same verification standard.
The published record runs deeper than any product page should. For the primary literature, browse GLP-3R studies on PubMed. For how every batch we sell is verified, see how we test.
From our research library: What research peptides actually are. · The incretin ladder: one, two, three receptors.
No. GLP-3R is supplied strictly for laboratory research. It is not for human or veterinary use, and every order requires agreement to our research-use policy.
The number of receptors engaged. GLP-1 activates the GLP-1 receptor alone, GLP-2T pairs it with the GIP receptor, and GLP-3R adds the glucagon receptor for a triple profile. Researchers often run them side by side to isolate what each added receptor contributes.
Glucagon signalling is associated with hepatic energy metabolism and increased energy expenditure in preclinical models. Adding it to the GLP-1/GIP pair is studied as a way to pair appetite-side signals with an expenditure-side signal in one molecule.
The current batch is 99.1% pure by HPLC, tested by an independent US laboratory before sale — along with identity confirmation and endotoxin screening below 0.5 EU/mg. The certificate of analysis is included with every order, and the report for any specific vial is available by emailing its lot number.
GLP-3R is available in 10mg, 20mg, 30mg and 50mg vials of lyophilized powder. Quantity discounts apply automatically at checkout.
Keep sealed vials frozen at −20 °C and away from light. Once reconstituted, hold the solution at 2–8 °C and use it within the window your laboratory protocol defines.
