ACTH (4–7) ANALOGUE
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Semax is built from a four-amino-acid fragment of ACTH, one of the body's stress hormones, with a short tail added to keep it stable. Like Selank, it was developed by Russian peptide researchers.
It's studied mainly for its effect on neurotrophins — the proteins, BDNF chief among them, that help neurons grow and survive — which keeps it a regular in neuroprotection models.
Keep the sealed vials in the fridge and out of direct light — they’ll hold up for a long time that way. Once a vial is mixed, keep it refrigerated and use it within the window your protocol calls for.
Every batch we sell is tested by an independent U.S. lab before it goes up for sale — that report is the certificate of analysis, and a copy is included with every order. Want the one for your exact vial? Email the lot number printed on the label to [email protected] and we’ll send it over within one business day.
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Also referenced as: ACTH(4-7)-Pro-Gly-Pro
Semax is a seven-amino-acid synthetic peptide built from a four-residue fragment of ACTH — the pituitary stress hormone — with a Pro-Gly-Pro tail added for stability. Crucially, the ACTH(4-7) fragment carries the parent hormone's neuroactive core while shedding its hormonal one: Semax does not drive the adrenal cortisol release ACTH exists to trigger.
Like Selank, it was developed in the Russian peptide-research tradition, and the two share both the stabilizing tail and much of their research culture.
The central thread is neurotrophins — above all BDNF, the growth factor neurons depend on for survival, plasticity and repair. Multiple studies report Semax exposure raising BDNF expression in brain tissue, which is the finding most of its neuroprotection literature builds on.
Around that core sit cerebral-ischemia models, cognition and attention studies in rodents, and gene-expression profiling of the vascular and immune response to brain injury. For labs studying how short peptides influence neurotrophin systems, Semax is one of the standard probes.
Verified at 99.0%+ purity, supplied lyophilized with batch-level identity and endotoxin testing. A robust heptapeptide by peptide standards; the usual discipline — frozen and dark as powder, cold and brief as solution — keeps it that way.
As with Selank, part of the primary literature lives in Russian-language journals; the PubMed search below surfaces the English-indexed body of work.
The published record runs deeper than any product page should. For the primary literature, browse Semax studies on PubMed. For how every batch we sell is verified, see how we test.
No. Semax is supplied strictly for laboratory research. It is not for human or veterinary use, and every order requires agreement to our research-use policy.
No — that's the design's point. Full ACTH drives the adrenal glands to release cortisol. The ACTH(4-7) fragment inside Semax retains the sequence's neuroactive properties without meaningful adrenal activity, letting researchers study the neural arm in isolation.
Because raised BDNF expression is the compound's most replicated experimental finding, and BDNF sits upstream of the plasticity and neuroprotection outcomes those studies measure. It's the mechanistic hinge of the literature.
The current batch is 99.0% pure by HPLC, tested by an independent US laboratory before sale — along with identity confirmation and endotoxin screening below 0.5 EU/mg. The certificate of analysis is included with every order, and the report for any specific vial is available by emailing its lot number.
Semax is available in 10mg vials of lyophilized powder. Quantity discounts apply automatically at checkout.
Keep sealed vials frozen at −20 °C and away from light. Once reconstituted, hold the solution at 2–8 °C and use it within the window your laboratory protocol defines.
