MITOCHONDRIAL-DERIVED PEPTIDE
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MOTS-c is an unusual one: a peptide encoded not in the cell's nucleus but inside the mitochondria themselves — part of a recently discovered class of signals the cell's power plants send to the rest of the body.
Research on it centers on metabolism and exercise physiology: AMPK signalling, glucose handling, and how mitochondria talk back to the cell when energy demand changes.
Keep the sealed vials in the fridge and out of direct light — they’ll hold up for a long time that way. Once a vial is mixed, keep it refrigerated and use it within the window your protocol calls for.
Every batch we sell is tested by an independent U.S. lab before it goes up for sale — that report is the certificate of analysis, and a copy is included with every order. Want the one for your exact vial? Email the lot number printed on the label to [email protected] and we’ll send it over within one business day.
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Also referenced as: mitochondrial-derived peptide MOTS-c · mitochondrial ORF of the 12S rRNA type-c
MOTS-c is a sixteen-amino-acid peptide with a genuinely unusual birthplace: it is encoded inside the mitochondrial genome, in a short open reading frame hidden within the 12S ribosomal RNA gene. Its 2015 discovery helped establish a new class of molecules — mitochondrial-derived peptides — signals the cell's power plants send to the rest of the cell and body.
That origin upended a long assumption that mitochondrial DNA encodes only respiratory-chain machinery. MOTS-c showed the organelle also writes its own signalling molecules.
The core literature is metabolic: MOTS-c has been reported to activate AMPK — the cell's low-fuel sensor — and to influence glucose handling and insulin sensitivity in rodent and cell models. Exercise physiology is the second major thread: muscle expression and circulating levels have been reported to respond to exercise, framing MOTS-c as a candidate 'exercise mimetic' signal under active investigation.
A third, striking finding drives newer work: under metabolic stress the peptide translocates to the nucleus and appears to act as a transcription-regulating signal — a mitochondrion reaching directly into nuclear gene expression. Retrograde signalling of that kind is one of the livelier corners of current mitochondrial biology.
Verified at 98.7%+ purity, supplied lyophilized with batch-level identity and endotoxin testing. Standard peptide discipline applies: −20 °C lyophilized and dark; cold, prompt use after reconstitution.
It pairs naturally with NAD+ in mitochondrial-focused study designs — one probes the organelle's energy currency, the other its outbound signalling.
The published record runs deeper than any product page should. For the primary literature, browse MOTS-c studies on PubMed. For how every batch we sell is verified, see how we test.
From our research library: NAD+, the molecule aging research runs on.
No. MOTS-c is supplied strictly for laboratory research. It is not for human or veterinary use, and every order requires agreement to our research-use policy.
It's encoded by the mitochondrion's own DNA rather than the nuclear genome. MOTS-c comes from a small open reading frame inside the mitochondrial 12S rRNA gene — part of a recently recognized family of such peptides that also includes humanin.
Because studies have reported that exercise raises its expression, and that administering it in rodent models reproduces some exercise-associated metabolic signatures, notably AMPK activation. Whether that framing fully holds is exactly what ongoing research is testing.
The current batch is 99.2% pure by HPLC, tested by an independent US laboratory before sale — along with identity confirmation and endotoxin screening below 0.5 EU/mg. The certificate of analysis is included with every order, and the report for any specific vial is available by emailing its lot number.
MOTS-c is available in 25mg and 50mg vials of lyophilized powder. Quantity discounts apply automatically at checkout.
Keep sealed vials frozen at −20 °C and away from light. Once reconstituted, hold the solution at 2–8 °C and use it within the window your laboratory protocol defines.
